{"id":3538,"date":"2022-07-21T16:03:03","date_gmt":"2022-07-21T16:03:03","guid":{"rendered":"https:\/\/www.inthedays.com\/?p=3538"},"modified":"2022-07-21T16:06:09","modified_gmt":"2022-07-21T16:06:09","slug":"new-long-covid-treatment-developed-at-tel-aviv-university","status":"publish","type":"post","link":"https:\/\/www.inthedays.com\/?p=3538","title":{"rendered":"NEW LONG-COVID TREATMENT DEVELOPED AT TEL AVIV UNIVERSITY"},"content":{"rendered":"\t\t
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KNOWLEDGE INCREASED<\/div>\n
\"But thou, O Daniel, shut up the words, and seal the book, even to the time of the end: many shall run to and fro, and \n
knowledge STRONG\u2019S 1847: <\/font>da\ua725ath, dah\u00b4-ath; from 3045; knowledge:\u2014cunning, (ig-)norantly, know(-ledge), (un-)awares (wittingly).<\/span><\/div> shall be increased.\"\n \u2014 Daniel 12:4<\/blockquote><\/strong><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Article Source: Jerusalem Post<\/span><\/a><\/b><\/span><\/div>\n

Patients with long-term COVID-19 symptoms who are exposed to hyperbaric (high-pressure oxygen) therapy (HBOT) intensive show a significant improvement in cognitive, neurological, and psychiatric functions.\u00a0<\/strong><\/p>\n

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Following a groundbreaking new study at\u00a0Tel Aviv University (TAU),<\/a>\u00a0the treatments were accompanied by advanced magnetic resonance imaging (MRI) imaging of the patients\u2019 brains, identifying damage from the COVID-19 virus and linking the images with clinical findings before and after HBOT treatment.\u00a0<\/strong><\/p>\n

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The first of its kind in the world, the study introduced a promising treatment for long-term COVID-19 symptoms based on advanced HBOT.\u00a0Long COVID,<\/a> which affects as many as a third of patients who were infected by the COVID-19 virus but weeks or months after they recover, is characterized by a range of debilitating cognitive symptoms such as\u00a0inability to concentrate and brain fog, forgetfulness, and difficulty recalling words or thoughts. These symptoms continue for more than three months and sometimes up to two years.\u00a0<\/strong><\/p>\n

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\u201cToday, we understand that in some patients, the COVID-19 virus penetrates the brain through the cribriform plate, the part of the skull located just above our nose, and triggers chronic brain injury\u00a0Prof. Shai Efrati, head of the Sagol Center and a faculty member at TAU\u2019s Sackler School of Medicine<\/strong><\/p>\n<\/blockquote>\n

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Until now, no effective therapy has been suggested, leaving many millions of sufferers around the world with no relief. The researchers said that the study \u201cis the first randomized, controlled trial to demonstrate a real solution for long COVID. Patients exposed to an intensive protocol of HBOT treatments showed significant improvement compared to the control group. For millions suffering from long-term COVID-19 symptoms, the study provides new hope for recovery.\u201d\u00a0<\/strong><\/p>\n

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\"Shamir Medical Center (credit: SHAMIR MEDICAL CENTER)<\/strong><\/p>\n

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The study, just published in the prestigious journal\u00a0Scientific Reports<\/em>\u00a0under the title \u201cHyperbaric oxygen therapy improves neurocognitive functions and symptoms of the post-COVID condition: Randomized controlled trial,\u201d was conducted by the Tel Aviv University and Shamir Medical Center (Assaf Harofeh). It was led by Prof. Shai Efrati, head of the Sagol Center and a faculty member at TAU\u2019s Sackler School of Medicine and Sagol School of Neuroscience, and by Dr. Shani Itskovich Zilberman from the Sagol Center for Hyperbaric Medicine and TAU\u2019s Sackler School of Medicine.<\/strong><\/p>\n

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Other chief contributors were Dr. Merav Catalogna, lead data scientist from the Shamir Medical Center, and Dr. Amir Hadanny from the Sagol Center and TAU\u2019s Sackler School of Medicine.\u00a0<\/strong><\/p>\n

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\u201cToday, we understand that in some patients, the COVID-19 virus penetrates the brain through the cribriform plate, the part of the skull located just above our nose, and triggers chronic brain injury \u2013 mainly in brain regions in the frontal lobe and responsible for cognitive function, mental status and pain interpretation,\u201d explained Efrati. \u201cConsequently, affected patients experience a long-term cognitive decline, with symptoms such as brain fog, loss of concentration, and mental fatigue. \u00a0In addition,\u00a0since the frontal lobe is damaged, patients may suffer from mood disturbance, depression, and anxiety.\u201d<\/strong><\/p>\n

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These clinical symptoms, identified in patients all over the world, were corroborated by the World Health Organization (WHO) in an official definition of so-called \u201clong COVID\u201d issued in October 2021, including cognitive dysfunction as one of the common symptoms. A recent study from the Universities of Cambridge and Exeter reported that 78% of long COVID patients had difficulties with concentration; 69% reported brain fog; and 68% complained of forgetfulness.\u00a0Thus, long-term COVID-19 effects can be very detrimental to the sufferer\u2019s quality of life, and no effective treatment has yet been found.\u00a0<\/strong><\/p>\n

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In the new TAU-led study, they used HBOT, which has already been proven effective in the treatment of other forms of brain injury, including stroke, trauma, age-related cognitive decline, and treatment-resistant PTSD, to the global effort to find a solution for long COVID-19.<\/strong><\/p>\n

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The study, designed as a prospective, randomized, double-blind, and placebo-controlled clinical trial, included 73 patients with reported post-COVID-19 cognitive symptoms such as inability to concentrate, brain fog, forgetfulness and difficulty recalling words or thoughts, persisting for more than three months following an RT-PCR test confirming COVID-19 infection.<\/strong><\/p>\n

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We believe that the beneficial effects of the unique treatment protocol in this study can be attributed to renewed neuroplasticity and increased brain perfusion in regions associated with cognitive and emotional roles.\u201d\u00a0Dr. Shani Itskovich Zilberman\u00a0<\/strong><\/p>\n<\/blockquote>\n

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Participants were divided into two groups \u2013 37 patients received HBOT treatment, while 36 patients served as a placebo-controlled group. Both patients and investigators were unaware of their designated treatment protocol. The unique protocol consisted of 40 daily HBOT sessions, five sessions per week within two months, in which patients entered a multi-place HBOT chamber and breathed 100% oxygen by mask at two atmospheres absolute (ATA) for 90 minutes with oxygen fluctuations. The control group received a placebo treatment, breathing normal air.\u00a0<\/strong><\/p>\n

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In addition, all participants underwent a computerized cognitive test, as well as advanced high-resolution brain imaging at two points in time \u2013 when entering the trial and after its completion.\u00a0<\/strong><\/p>\n

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Encouraging results<\/strong><\/h3>\n

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The results were very encouraging. Patients treated with HBOT showed significant improvement, while in control group long COVID symptoms remained largely unchanged. In HBOT-treated patients, the greatest improvements were exhibited in the global cognitive function, attention, and executive functions (the capacity to plan, organize, initiate, self-monitor and control one\u2019s responses in order to achieve a goal). Other benefits included better information processing speed, improved psychiatric symptoms, more mental energy, better sleep quality, and less body pain.\u00a0All clinical findings were correlated with the participants\u2019 brain images, indicating significant changes in the parts of the brain related to each function, which had been visibly damaged by the COVID-19 virus.\u00a0<\/strong><\/p>\n

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Itskovich Zilberman said that \u201cwe know that HBOT repairs brain damage through a process of regeneration \u2013 generating new neurons and blood vessels. We believe that the beneficial effects of the unique treatment protocol in this study can be attributed to renewed neuroplasticity and increased brain perfusion in regions associated with cognitive and emotional roles.\u201d<\/strong><\/p>\n

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\u201cFor the first time, our study proposes an effective treatment for the debilitating long COVID syndrome, repairing brain injury with an intensive protocol of HBOT,\u201d concluded Efrati.\u00a0\u201cMoreover, the study reveals the very real biological damage to brain tissues induced by the COVID-19 virus and how repairing this damage reduces symptoms and can eventually lead to recovery. From a broader perspective, these findings can also suggest that other neurological and psychiatric syndromes might be triggered by biological agents such as viruses, opening new possibilities for future treatments.\u201d \u00a0<\/strong><\/p>\n

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SARS-CoV-2, the novel coronavirus behind COVID-19 (Illustrative).
\n(photo credit: fusion medical animation\/unsplash)<\/p>\n

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Effective high-pressure oxygen treatment is now available for millions suffering from long-term COVID-19 symptoms.<\/font><\/strong><\/h5>\n","protected":false},"author":3,"featured_media":3542,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pmpro_default_level":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-3538","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-knowledge-increased","pmpro-has-access"],"_links":{"self":[{"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/posts\/3538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3538"}],"version-history":[{"count":6,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/posts\/3538\/revisions"}],"predecessor-version":[{"id":3545,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/posts\/3538\/revisions\/3545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/media\/3542"}],"wp:attachment":[{"href":"https:\/\/www.inthedays.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}