{"id":1641,"date":"2020-04-02T17:49:14","date_gmt":"2020-04-02T17:49:14","guid":{"rendered":"https:\/\/www.inthedays.com\/?p=1641"},"modified":"2020-04-02T17:57:45","modified_gmt":"2020-04-02T17:57:45","slug":"israeli-scientists-coronavirus-vaccine-to-be-tested-on-humans-by-june-1","status":"publish","type":"post","link":"https:\/\/www.inthedays.com\/?p=1641","title":{"rendered":"ISRAELI SCIENTISTS: CORONAVIRUS VACCINE TO BE TESTED ON HUMANS BY JUNE 1"},"content":{"rendered":"\t\t
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Knowledge Increased<\/div>\n
\"But thou, O Daniel, shut up the words, and seal the book, even to the time of the end: many shall run to and fro, and knowledge shall be \n\n
increased STONG\u2019S NUMBER:7235 <\/font>rabah, raw-baw\u00b4; a primitive root; to increase (in whatever respect):\u2014(bring in) abundance (x -antly), + archer (by mistake for 7232), be in authority, bring up, x continue, enlarge, excel, exceeding(-ly), be full of, (be, make) great(-er, -ly, x -ness), grow up, heap, increase, be long, (be, give, have, make, use) many (a time), (any, be, give, give the, have) more (in number), (ask, be, be so, gather, over, take, yield) much (greater, more), (make to) multiply, nourish, plenty(-eous), x process (of time), sore, store, thoroughly, very<\/span><\/div>.\"\n\n \u2014 Daniel 12:4 <\/blockquote><\/div>\n\n
\u201cAnd the LORD said, Behold, the people is one, and they have all one language; and this they begin to do: and now nothing will be restrained from them, which they have\n\n
imagined Strongs 2161: <\/font> zamam, zaw-mam\u00b4; a primitive root; to plan, usually in a bad sense:\u2014consider, devise, imagine, plot, purpose, think (evil).<\/span><\/div> to do.\n\n \u2014 Genesis 11:6<\/blockquote><\/strong><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Article Source:<\/span> Jerusalem Post<\/span><\/a><\/span><\/strong><\/span><\/p>\n

A team of Israeli researchers says that they are days away from completing the production of the active component of a\u00a0coronavirus\u00a0vaccine that could be tested on humans as early as June 1.\u201cWe are in the final stages and within a few days we will hold the proteins \u2013 the active component of the vaccine,\u201d Dr. Chen Katz, group leader of MIGAL\u2019s biotechnology group, told\u00a0The Jerusalem Post<\/em>.<\/p>\n

In late February, MIGAL [The Galilee Research Institute] committed to completing the production of its vaccine within three weeks and having it on the market in 90 days. Katz said they were slightly delayed because it took longer than expected to receive the genetic construct that they ordered from China due to the airways being closed and it has to be rerouted. As a reminder, for the past four years, researchers at MIGAL scientists have been developing a vaccine against infectious bronchitis virus (IBV), which causes a bronchial disease affecting poultry. The effectiveness of the vaccine has been proven in preclinical trials carried out at the Veterinary Institute.\u201cOur basic concept was to develop the technology and not specifically a vaccine for this kind or that kind of virus,\u201d said Katz. \u201cThe scientific framework for the vaccine is based on a new protein expression vector, which forms and secretes a chimeric soluble protein that delivers the viral antigen into mucosal tissues by self-activated endocytosis, causing the body to form antibodies against the virus.\u201dEndocytosis is a cellular process in which substances are brought into a cell by surrounding the material with the cell membrane, forming a vesicle containing the ingested material. In preclinical trials, the team demonstrated that the oral vaccination induces high levels of specific anti-IBV antibodies, Katz said.<\/p>\n\n

\u201cLet\u2019s call it pure luck,\u201d he said. \u201cWe decided to choose coronavirus as a model for our system just as a proof of concept for our technology.\u201dBut after scientists sequenced the DNA of the novel coronavirus causing the current worldwide outbreak, the MIGAL researchers examined it and found that the poultry coronavirus has high genetic similarity to the human one and that it uses the same infection mechanism, which increased the likelihood of achieving an effective human vaccine in a very short period of time, Katz said. To ensure they come close to the deadline they set for themselves, MIGAL is concurrently working with the relevant regulators to ensure the product will be considered safe for human trials. He explained that because it will be an oral vaccine, \u201cthe quality of this kind of vaccine should be closer to food regulations than pharma regulations or somewhere in between. We hope that we will not need to go through the complete purification process like in the drug industry because that could delay us.\u201dThe group also started trials on mice to support their previous trials on chickens. Katz said phase I human trials would be conducted on \u201cyoung, healthy individuals\u201d and then would likely expand to the general population. The group, which is funded in part by a NIS 30 million grant from the Science and Technology Ministry, is in touch with the Health Ministry, he said and noted that \u201ctechnology-wise, people wise we have all we need in Israel.\u201d He believes the vaccine will first be available in the Jewish state February, Science and Technology Minister Ofer Akunis said he had instructed his ministry\u2019s director-general to fast-track all approval processes with the goal of bringing the human vaccine to market as quickly as possible. On Wednesday, a representative from his ministry said it would not be directly involved in the regulatory process.\u00a0According to Katz, close to 100 research teams around the world are currently focused on developing a vaccine or treatment for the novel virus, including several in Israel. In fact, on Tuesday, another company, the Israel Institute for Biological Research (IIBR), told Reuters that it had begun testing a COVID-19 vaccine prototype on rodents at its biochemical defense laboratory. Prime Minister Benjamin Netanyahu ordered the IIBR, in rural Ness Ziona, to join the fight against the coronavirus pandemic on February 1, prompting an easing of its secrecy as it cooperates with civilian scientists and private firms. In a statement, Netanyahu’s office said IIBR director Shmuel Shapira had informed him of “significant progress” in designing a vaccine prototype and that the institute “is now preparing a model for commencing an animal trial.”A source familiar with IIBR activities told Reuters that trials were already under way on rodents. The source declined to identify the kind of rodent.In rare public comments, IIBR chief innovation officer Eran Zahavy said last week that the institute had shifted its entire focus to the new coronavirus, with three groups trying to develop a vaccine against the COVID-19 disease it causes, and others researching potential treatments.”We are trying as much as we can to collaborate and have other ideas of other people,” he said at last week’s English-language online conference hosted by Jerusalem Venture Partners.”But the facility of the lab is very crowded and very busy and very dangerous, so it has to be very slow and very cautious.”Zahavy described arranging an animal test subject as “a very big challenge” because “this disease is not affecting animals.”Shapiro added that many experiments that are successful in animals are not always successful when tested on human test subjects.”It’s not enough only to detect neutralizing antibodies in the animal. You really want to see them getting sick and getting better by this vaccine,” he said.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

MIGAL and IIBR are both testing potential COVID-19 vaccinations on mammals<\/p>\n","protected":false},"author":3,"featured_media":1644,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"pmpro_default_level":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-1641","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-knowledge-increased","pmpro-has-access"],"_links":{"self":[{"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/posts\/1641","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1641"}],"version-history":[{"count":8,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/posts\/1641\/revisions"}],"predecessor-version":[{"id":1650,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/posts\/1641\/revisions\/1650"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=\/wp\/v2\/media\/1644"}],"wp:attachment":[{"href":"https:\/\/www.inthedays.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1641"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1641"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.inthedays.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}